Researchers of the Helmholtz Centre for Infection Research HZI and the Braunschweig Integrated Centre of Systems Biology BRICSin collaboration with researchers at the University of Oxford UKhave now simulated the dynamic arrangement of these components using computer models and have subsequently been able to make inferences on the mechanisms involved in the formation of synapses. The loose bond formed between the two cell surfaces allows for the binding of T-cell receptors to the presented antigen. Microscope image shows an immunological synapse. If all the components of the synapse are correctly positioned, activation of the immune cell will result. Dysfunction of the brain causes severe physical and mental impairments, especially during aging, and are among the most frequent medical disorders. Necessary cookies Only cookies permitted that are required for the basic functionality of our websites. It combines biomedical experiments with theoretical models and thereby opens new avenues for scientific insights and technological applications.
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Press Release – Helmholtz Zentrum München
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The same kind of models can also be used for investigating complex neurological malfunctions. This temporal view of tissue metabolism gives us better insight into how metabolism is changed in metabolic diseases, for example, in the case of obesity and diabetes. The aim is to develop novel strategies for personalized prevention and treatment of diabetes.
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The Institute of Diabetes and Obesity IDO studies the diseases of the metabolic syndrome by means of systems biological and translational approaches on the basis of cellular systems, genetically modified mouse models and clinical intervention studies.
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HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy. Dominik Lutter und Dr.
The ring pattern is thus a result of mechanical forces in the cell membrane which sorts the molecules in the synapse according to their size. Overall, the study provides an overview of the metabolic processes taking place in the respective tissue at any given time, and also reveals previously unknown links.
These included the suprachiasmatic nucleus in the hypothalamus regarded as the principal circadian pacemaker in mammalsin addition to prefrontal cortex, skeletal muscle, liver, brown and white adipose tissue, blood and sperm.
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|We only use this information for improving our services. Computational Neurocience The new, highly dynamic research discipline of Computational Neuroscience takes up these challenges.
To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. There you may also change your settings later. Vimeo, Twitter, Googlemaps Permit embedded content and cookies from third party providers. Third party content and cookies e.
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The same kind of models can also be used for investigating complex neurological malfunctions. Involved Groups Systems Immunology. These changes have major implications for how diet can contribute to development of muscle insulin resistance.
Computational Neuroscience will help to soothe the devastating effects of neurological diseases and aging, by developing new approaches for therapies and testing them safely in computer simulations, restoring challenged brain functions by new, intelligent implants and prostheses, and developing intelligent technical devices with brain-inspired sensors that take care of complex tasks in a reliable and safe way.
We use different types of cookies. This, however, could not be proved for the other molecules.